转化生长因子-β在特发性肺纤维化中的研究新进展

赵存刚,黄文海,王尊元,沈正荣,马臻

中国药学杂志 ›› 2016, Vol. 51 ›› Issue (5) : 341-345.

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中国药学杂志 ›› 2016, Vol. 51 ›› Issue (5) : 341-345. DOI: 10.11669/cpj.2016.05.001
综 述

转化生长因子-β在特发性肺纤维化中的研究新进展

  • 赵存刚,黄文海,王尊元,沈正荣,马臻*
作者信息 +

Role of TGF-β in Idiopathic Pulmonary Fibrosis

  • ZHAO Cun-gang, HUANG Wen-hai, WANG Zun-yuan, SHEN Zheng-rong, MA Zhen*
Author information +
文章历史 +

摘要

特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种原因不明、以弥漫性肺泡炎和肺泡结构紊乱最终导致肺间质纤维化为特征的疾病。该病预后不良,目前尚缺乏疗效显著的治疗方法。转化生长因子-β (transforming growth factor-β, TGF-β)是特发性肺纤维化过程中关键的致纤维化因子,可促进肺泡上皮细胞凋亡、纤维细胞的活化和生成以及细胞外基质沉积等肺纤维化中的多个关键步骤。充分认识转化生长因子-β在特发性肺纤维化发生发展中的作用,对治疗具有重大意义。笔者就近年来国内外对转化生长因子-β在特发性肺纤维化中的研究最新进展进行综述。

Abstract

Idiopathic pulmonary fibrosis (IPF) is a typical chronic, progressive fibrosing interstitial pneumonia, which is clinical characterized by progressive worsening of dyspnea and lung function with a poor prognosis. Since the pathogenesis is not clear, there is no efficiency cure for IPF until now. It is discovered that transforming growth factor-β (TGF-β), a “master switch” in the formation and development of IPF, plays an important role in the regulation of alveolar epithelial cells apoptosis, and the promotion of epithelial to mesenchymal transition and extracellular matrix synthesis. In this paper, the latest impacts of TGF-β on IPF are reviewed, which may provide the clues and evidence for the development of anti pulmonary fibrotic drugs.

关键词

特发性肺纤维化 / 转化生长因子-β / 上皮-间质转化 / 细胞外基质

Key words

idiopathic pulmonary fibrosis / transforming growth factor-β / epithelial-to-mesenchymal transition / extracellular matrix

引用本文

导出引用
赵存刚,黄文海,王尊元,沈正荣,马臻. 转化生长因子-β在特发性肺纤维化中的研究新进展[J]. 中国药学杂志, 2016, 51(5): 341-345 https://doi.org/10.11669/cpj.2016.05.001
ZHAO Cun-gang, HUANG Wen-hai, WANG Zun-yuan, SHEN Zheng-rong, MA Zhen. Role of TGF-β in Idiopathic Pulmonary Fibrosis[J]. Chinese Pharmaceutical Journal, 2016, 51(5): 341-345 https://doi.org/10.11669/cpj.2016.05.001
中图分类号: R965   

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基金

浙江省自然科学基金资助项目(LY16H310010);浙江省医学重点学科群资助项目(XKQ-010-001)
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